A simple, sensitive, accurate, rapid, and economical spectrophotometric method has been developed for the determination of PPX in bulk drug and pharmaceutical formulations. The method is based on the reduction of iron (III) by the drug and subsequent interaction of iron (II) with ferricyanide to form green colored chromogen. The product exhibit maximum absorbance at 789.0 nm against reagent blank. Beer's law was obeyed in the concentration range of 1.0-5.0 µg/ml with correlation coefficient (r2) of 0.9992. The limit of detection (LOD) and limit of quantification (LOQ) were 0.082 µg/ml and 0.249 µg/ml, respectively. Results of the analysis were validated statistically and by recovery studies. The results are compared with previously developed UV spectrophotometric method. Commercial tablet formulation was successfully analyzed using the developed method.
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